The fiber diameter increased with increasing flow rate, while there was no substantial influence of the air gap. Scaffolds were electrospun at different flow rates and distances between spinneret and collector (air gap), and the resulting meshes were characterized in terms of fiber morphology, diameter, and mesh inter-fiber pore size. Polyethylene oxide (PEO), PCL, and PEOT/PBT were used as a carrier of Alginate. Thus, this study aims at creating electrospun meshes made of blended synthetic and natural polymers for tissue engineering applications. While synthetic polymers can mimic the physical features of native ECM, natural polymers like alginate are better suited to recapitulate its hydrated state or introduce functional groups that are recognized by cells (e.g., –NH 2). Synthetic polymers as poly (ε-caprolactone) (PCL) and poly (ethylene oxide terephthalate)-poly(butylene terephthalate) (PEOT/PBT) have been often used to produce scaffolds due to their good processability, mechanical properties, and suitable biocompatibility. 2MERLN Institute for Technology-inspired Regenerative Medicine, Complex Tissue Regeneration Department, Maastricht University, Maastricht, NetherlandsĮlectrospinning is an attractive fabrication process providing a cost-effective and straightforward technic to make extra-cellular matrix (ECM) mimicking scaffolds that can be used to replace or repair injured tissues and organs.1Tissue Regeneration Department, Institute for BioMedical Technology and Technical Medicine, University of Twente, Enschede, Netherlands.Ana Rita Gonçalves de Pinho 1 Ines Odila 1 Anne Leferink 1 Clemens van Blitterswijk 1,2 Sandra Camarero-Espinosa 2 Lorenzo Moroni 1,2 *
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